A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes
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چکیده
Kaisa Silander, Laura J. Scott, Timo T. Valle, Karen L. Mohlke, Heather M. Stringham, Kerry R. Wiles, William L. Duren, Kimberly F. Doheny, Elizabeth W. Pugh, Peter Chines, Narisu Narisu, Peggy P. White, Tasha E. Fingerlin, Anne U. Jackson, Chun Li, Soumitra Ghosh, Victoria L. Magnuson, Kimberly Colby, Michael R. Erdos, Jason E. Hill, Pablo Hollstein, Kathleen M. Humphreys, Roshni A. Kasad, Jessica Lambert, Konstantinos N. Lazaridis, George Lin, Anabelle Morales-Mena, Kristin Patzkowski, Carrie Pfahl, Rachel Porter, David Rha, Leonid Segal, Yong D. Suh, Jason Tovar, Arun Unni, Christian Welch, Julie A. Douglas, Michael P. Epstein, Elizabeth R. Hauser, William Hagopian, Thomas A. Buchanan, Richard M. Watanabe, Richard N. Bergman, Jaakko Tuomilehto, Francis S. Collins, and Michael Boehnke
منابع مشابه
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14.
The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage r...
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We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of </=40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nomina...
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We undertook a systematic search of the entire human genome with the affected sibling-pair model to identify major susceptibility loci to essential hypertension. Affected nuclear families (n=263) were recruited and divided according to definite or probable genetic contribution to hypertension depending on number of hypertensive siblings. The largest nuclear families were first screened with a s...
متن کاملThe Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed diabetic and nondiabetic subjects separat...
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تاریخ انتشار 2004